Influence our happiness, create better states byĭesigning your experiences to improve your mental chemistry and There are four major chemicals in the brain that Happiness, The Greater Good From Berkley University.
States, how they are created and how to have more of theseīlog: The Neurochemistry of Happiness, The Hormones of Gratitude, resilience, love, compassion.and desired/interrelated Lama and happiness, shakti, and telling his holiness a Happiness hacks, strategies of happiness, That have some level of science to back them up. There are over 20 happiness hacks and strategies
Matters and has to be balanced with Anger and a true driver of The research produced by Sébastien Granier (and Brian Kobilka’s team in Stanford) resolved the 3D structure of μ-opioid receptors when associated with a molecule that has a similar chemical structure to morphine.Of Success?" Wait What? I Thought It was Anger!įrees and Somnath Sikdar (Alex is away) examine why happiness “ It is therefore essential to understand the structural bases of morphine action, and opioids in general, if we are to develop molecules that retain the beneficial effects of morphine whilst eliminating the side effects,” explains Sébastien Granier, Inserm researcher and project leader. Since morphine and endorphins bind with the same receptor, the two molecules stabilize the μ-opioid receptors in separate spatial conformations that cause the differences in biological responses. These harmful effects can be explained by the fact that morphine triggers a cellular response that differs from that triggered by endorphins. Furthermore, morphine consumption has serious side effects: respiratory depression, constipation, physical and psychic dependency. Secondly, morphine consumption can lead to drug dependency (heroin, the acetylated form of morphine, is the most obvious example). Firstly, the development of a tolerance phenomenon means that, in the case of repeated injections, the morphine dose must be increased to obtain the same therapeutic effect. However, its clinical use is limited by two effects. These receptors are part of a superfamily of proteins, G protein-coupled receptors (GPCR), which are the target of around 30% of drugs currently on the market.Īt a molecular level, morphine binds with μ-opioid receptors to imitate the action of molecules produced naturally in the brain: endorphins. Morphine’s action is relayed by μ-opioid receptors expressed at the surface of cells in the central nervous system. Today morphine has widespread clinical pain-relief applications. These effects are caused by its major component: morphine. Opium is a natural poppy (papaver somniferum) extract and is one of the oldest drugs known to man, used for its psychotropic, sedative and analgesic properties. The results were published in the Nature review on 21 March 12. Thanks to this discovery, the researchers have now set their sights on retaining the benefits of morphine while eliminating any undesired side effects. The 3D structure of brain receptors is likely to differ, depending on the type of molecule bound upon it (morphine or endorphin): the body’s response will be completely and accordingly modified. So why does it have such harmful side effects? This question has recently been elucidated by Sébastien Granier, researcher at the Institute of Functional Genomics (Inserm/CNRS/Universités de Montpellier 1 and 2) and his team, in conjunction with collaborators in the US.
Morphine imitates the action of molecules produced naturally by the brain (endorphins). However, its pain-relief properties are coupled with considerable side effects. Morphine has been used for centuries to relieve severe pain.